Combining antihypertensive and antihyperlipidemic agents – optimizing cardiovascular risk factor management

Combining antihypertensive and antihyperlipidemic agents – optimizing cardiovascular risk factor management

Clinical guidelines now recognize the importance of a multifactorial approach to managing cardiovascular (CV) risk. This idea was taken a step further with the concept of the Polypill™. There are, however, considerable patent, pharmacokinetic, pharmacodynamic, registration, and cost implications that will need to be overcome before the Polypill™ or other single-pill combinations of CV medicatio...

Optimizing cardiovascular risk reduction during antihypertensive therapy.

Over the past decade, pharmacological treatment of elevated blood pressure has evolved from empiricism to a more individualized approach based on patient characteristics and an expanding understanding of the impact of specific agents on the pathophysiology of hypertension and, more importantly, cardiovascular disease. Although blood pressure elevation has been shown to be a powerful risk factor...

Lovastatin and coadministered antihypertensive/cardiovascular agents.

Hypertension and hypercholesterolemia frequently coexist and may require concomitant drug treatments. The efficacy and safety profile of lovastatin given in the presence of antihypertensive medication was evaluated using patient subgroups identified in the Expanded Clinical Evaluation of Lovastatin (EXCEL) Study. The EXCEL study examined 8,245 patients with moderate hypercholesterolemia randoml...

Atherosclerosis and Antihyperlipidemic Agents

Heart rate as a risk factor for atherosclerosis and cardiovascular mortality: the effect of antihypertensive drugs.

The aim of this review is to highlight the importance of heart rate (HR) as a risk factor for cardiovascular disease, and to discuss the classes of drugs which can be potentially useful in clinical conditions in which an elevated HR may be present. Numerous studies have shown that high resting HR is prospectively related to the development of atherosclerosis and of cardiovascular events. This r...